Deafness from Dihydrostreptomycin
نویسندگان
چکیده
منابع مشابه
Deafness in tuberculous meningitis with a comparison between streptomycin, (calcium chloride complex) and dihydrostreptomycin.
The successful clinical results obtained with dihydrostreptomycin in clinical and experimental tuberculosis and its comparative lack of neurotoxicity as reported by Edison et al. (1948), Feldman et al. (I948), Hinshaw et al. (1948) and Hobson et al. (I948) led to the general introduction of this drug into the therapy of tuberculosis. We have been using this drug since I949, but in concert with ...
متن کاملDihydrostreptomycin produced by direct fermentation.
.Most of the streptomycin produced in the United States (342,000 kg in 1958) is sold as dihydrostreptomycin. Production of dihydrostreptomycin from streptomycin entails catalytic hydrogenation followed by a crystallization. Production of dihydrostreptomycin directly by fermentation would have the advantage of simplicity of purification with its attendant economic advantage. Our antibiotics scre...
متن کاملA synthesis of dihydrostreptomycin.
A key protected streptidine derivative (3) useful for the synthesis of antibiotics of streptomycin series was prepared by hydrolysis of an acylated dihydrostreptomycin (DHSM) derivative (2), and it was condensed with a protected dihydrostreptobiosaminyl chloride (5) to give two condensation products (6 and 7). By deblocking, 6 was led to DHSM and 7 to a biologically inactive isomer (8) of DHSM....
متن کاملStudies on Some Biological Aspects of Dihydrostreptomycin.
The catalytic conversion of streptomycin to a dihydro compound was recently described and some of the biological characteristics of the latter were noted (Peck et al., 1946; Fried and Wintersteiner, 1947; Bartz et al., 1946). Peck and his coworkers (1946) reported that dihydrostreptomycin showed in vitro activity against Bacillus subtilis, and Bartz et al. (1946) also reported activity against ...
متن کاملEffect of Dihydrostreptomycin in Pleurisy with Effusion
The effect of dihydrostreptomycin in pleurisy with effusion was studied in the following five cases. The diagnosis of effusion was established in every case by paracentesis thoracis. Presence of lymphocytosis, absence of any organism as evidenced by microscopic examination, and the fluid turning out sterile on culture led to the conclusion that the condition was due to a tuberculous focus in th...
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ژورنال
عنوان ژورنال: BMJ
سال: 1951
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.4732.651